Federal Register: May 19, 2004 (Volume 69, Number 97)
DOCID: FR Doc 04-11359
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
NOTICE: NOTICES
ACTION: Meetings:
SUBJECT CATEGORY:
National Toxicology Program; Call for Public Comments on 21 Substances, Mixtures and Exposure Circumstances Proposed for Listing in the Report on Carcinogens, Twelfth Edition
DOCUMENT SUMMARY:
Background
The National Toxicology Program (NTP) announces its intent to review additional agents, substances, mixtures and exposure circumstances for possible listing in the Report on Carcinogens (RoC), Twelfth Edition that is scheduled for publication in 2006. This Report (previously known as the Annual Report on Carcinogens) is a Congressionally mandated listing of known human carcinogens and reasonably anticipated human carcinogens and its preparation is delegated to the NTP by the Secretary, Department of Health and Human Services (DHHS). Section 301(b)(4) of the Public Health Service Act, as amended, provides that the Secretary, DHHS shall publish a report, which contains a list of all substances (1) which either are known to be human carcinogens or may reasonably be anticipated to be human carcinogens, and (2) to which a significant number of persons residing in the United States (US) are exposed. The law also states that the reports should provide available information on the nature of exposures, the estimated number of persons exposed and the extent to which the implementation of Federal regulations decreases the risk to public health from exposure to these chemicals.
A nomination recommended for review in the RoC is evaluated
initially by the NIEHS/NTP RoC nomination review committee, composed of
scientists from the NIEHS/NTP staff, to determine if the information
available for a nomination indicates the criteria for listing can be
applied and warrants formal consideration by the NTP. The scientific
review of a nomination involves three separate scientific reviews: two
Federal review groups and one nongovernment peer review body (a
subcommittee of the NTP Board of Scientific Counselors) that meets in
an open, public forum. Throughout the review process, multiple
opportunities are provided for public input including comment at the
public meeting of the NTP Board RoC Subcommittee. In reviewing
nominations for the RoC, all available data and public comments are
considered in the application of the criteria for inclusion or removal of candidate agents, substances, mixtures
[[Page 28941]]
or exposure circumstances or for a change in a candidate's classification.
The criteria used in the review process and a detailed description
of the review procedures, including the steps in the current formal
review process, can be obtained from the NTP Web site at http://ntpserver.niehs.nih.gov (see Report on Carcinogens) or can be obtained by
contacting: Dr. C. W. Jameson, National Toxicology Program, Report on
Carcinogens, 79 Alexander Drive, Building 4401, Room 3118, P.O. Box
12233, Research Triangle Park, NC 27709; phone: (919) 5414096, fax:
(919) 5410144, email: jameson@niehs.nih.gov. Public Comment Requested
The following table identifies the 21 nominations that the NTP may consider for review in 2004 or 2005, as either a new listing in or changing the current listing in the Twelfth Report. These nominations are provided with their Chemical Abstracts Services (CAS) Registry numbers (where available) and pending review action. Additional nominations for the Twelfth Report or modifications to the nominations in the attached table may be identified and would be announced in future Federal Register notices. The NTP solicits public input on these 21 nominations and asks for relevant information concerning their carcinogenesis, as well as current production data, use patterns, or human exposure information. The NTP also invites interested parties to identify any scientific issues related to the listing of a specific nomination in the RoC that they feel should be addressed during the reviews. Comments concerning these nominations for listing in or changing the current listing in the Twelfth Report on Carcinogens will be accepted for a period of 60 days from the publication date of this announcement in the Federal Register. Individuals submitting public comments are asked to include relevant contact information (name, affiliation (if any), address, telephone, fax, and email). Comments or questions should be directed to Dr. C. W. Jameson at the address listed above.
Additional Nominations Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for review for the Twelfth and future RoCs. Nominations should
contain a rationale for review. Appropriate background information and
relevant data (e.g., journal articles, NTP Technical Reports, IARC
listings, exposure surveys, release inventories, etc.), which support
the review of a nomination, should be provided or referenced when
possible. Contact information for the nominator should also be included
(name, affiliation (if any), address, telephone, fax, and email).
Nominations should be sent to Dr. Jameson's attention at the address given above.
Dated: May 10, 2004.
Kenneth Olden,
Director, National Toxicology Program.
Summary for Agents, Substances, Mixtures or Exposure Circumstances To Be Reviewed in 20042005 for Possible
Listing the Report on Carcinogens, Twelfth Edition Primary uses or
Nomination to be reviewed/CAS No. exposures Nominated by Basis for nomination
AristolochiaRelated Remedies........ Several Aristolochia NIEHS \1\.............. Herbal remedies
Herbal species containing the plant
(notably A. contorta, genus Aristolochia:
A. debilis, A. fangchi IARC \2\ finding of
and A. manshuriensis) sufficient evidence of
have been used in carcinogenicity in
traditional Chinese humans (Vol. 83,
medicine as anti 2002). rheumatics, as
diuretics, in the
treatment of edema and
for other conditions
such as hemorrhoids, coughs and asthma.
Aristolochic Acid................... Aristolochic acid, the NIEHS \1\.............. Naturally occurring
principle extract from mixtures of
Aristolochia, is a aristolochic acids:
mixture of IARC \2\ finding of
nitrophenanthrene sufficient evidence of
carboxylic acids. carcinogenicity in
animals and limited
evidence in humans
(Vol. 83, 2002).
Asphalt fumes........................ Asphalt is a petroleum John Schelp of NAACP Human epidemiological
product used in paving Durham Chapter. studies have reported
and roofing an increased risk in
operations. Asphalt lung cancer among
fumes are a cloud of workers exposed to
small particles asphalt fumes and
generated from the asphalt fumes caused
gaseous state after skin tumors in
volatilization of experimental animals.
asphalt aggregates. Additionally, known
human carcinogens
(PAHs) have been found
in asphalt fumes.
Atrazine (192249).................. Atrazine is an NIEHS \1\.............. IARC \2\ finding of
herbicide used to sufficient evidence of
control grass and carcinogenicity in
broadleaved weeds. animals (Vol. 73,
Atrazine has been 1999). detected at levels
that exceeded or
approached the MCL for atrazine in 200
community surface
drinking water system. [[Page 28942]]
Benzofuran (271896)................ Benzofuran is produced NIEHS \1\.............. Results of a NTP
by isolation from coal bioassay (TR 370,
tar oils. Benzofuran 1989) that reported
is used in the clear evidence of
manufacture of carcinogenicity in
coumaroneindene male and female mice
resins, which harden and some evidence of
when heated and are carcinogenicity in
used to make floor female rats. titles and other
products.
Captafol (24250601)................ Captafol is a fungicide NIEHS \1\.............. IARC \2\ finding of
that has been widely sufficient evidence of
used since 1961 for carcinogenicity in
the control of fungal animals (Vol. 53,
diseases in fruits, 1991). IARC also noted
vegetables and some that captafol is
other plants. Use of positive in many
captafol in the United genetic assays,
States was banned in including the invivo
1999. assay for dominant
lethal mutation.
Cobalt/TungstenCarbide Hard Metal Hardmetals are NIEHS \1\.............. Recent human cancer
Manufacturing. manufactured by a studies on the hard
process of powder metal manufacturing
metallurgy from industry an
tungsten and carbon association between
(tungsten carbide), exposure to hard
and small amounts of metals (cobalt
other metallic tungstencarbide) and
compounds using cobalt lung cancer. as a binder. Hard
metals are used to
make cutting and
grinding tools, dies,
and wear products for
a broad spectrum of
industries including
oil and gas drilling, and mining.
Di (2ethylhexyl) phthalate (DEHP) DEHP is mainly used as Jun KiChul, President Currently listed in the
(117817). a plasticizer in of Aekyung RoC as reasonably
polyvinyl chloride Petrochemical Co., LTD anticipated to be a
(PVC) resins for of Seoul, Korea (for human carcinogen.
fabricating flexible delisting). IARC reclassification
vinyl products. PVC as not classifiable as
resins have been used to its carcinogenicity
to manufacture toys, to humans (Group 3)
dolls, vinyl (Vol. 73, 2000). IARC
upholstery, stated that there is
tablecloths and many sufficient evidence
other products. for the
carcinogenicity in
experimental animals;
however, the mechanism
for liver tumor
involves peroxisome
proliferation that is
not relevant to
humans.
Etoposide in combination with Etoposide in NIEHS \1\.............. IARC \2\ finding of
cisplatin and bleomycin. combination with sufficient evidence of
cisplatin and carcinogenicity in
bleomycin is used to humans (Vol 76, 2000).
treat testicular germ cell cancers.
Etoposide (33419420)............... Etoposide is a DNA NIEHS \1\.............. IARC \2\ finding of
topoisomerase II limited evidence of
inhibitor used in carcinogenicity in
chemotherapy for non humans (Vol. 76,
Hodgkin's lymphoma, 2000). smallcell lung
cancer, testicular
cancer, lymphomas and
a variety of childhood malignancies.
Glass wool (respirable size): Two The major uses of glass North American Glass wool (respirable
nominations: (1) Insulation glass wool are in thermal, Insulation size) is currently
wool fibers (2) Special purposes electrical, and Manufacturers listed in the RoC as
glass fibers. acoustical insulation, Association nominated reasonably anticipated
weatherproofing, and glass wool (respirable to be a human
filtration media. In size) for delisting. carcinogen.
1980, approximately Special purpose glass Insulation glass wool:
80% of the glass wool wool fibers: NIEHS \1\. IARC \2\ finding of
produced for limited evidence of
structural insulation carcinogenicity in
was used in houses. animals and evaluation
Special purpose fibers as not classifiable as
are used for high to its carcinogenicity
efficiency air to humans (Group 3)
filtration media, and (Vol. 81, 2002).
acid battery Specialpurpose glass
separators. fibers: IARC \2\
finding of sufficient
evidence of
carcinogenicity in
animals (Vol. 81,
2002). [[Page 28943]]
Metalworking Fluids.................. Metal working fluids NIEHS \1\.............. Recent human cancer
are complex mixtures studies of metal
that may contain working fluid that
mixtures of oil, show an association
emulsifiers, antiweld between exposure to
agents, corrosion these materials and
inhibitors, extreme cancer at several
pressure additives, tissue sites.
buffers biocides and
other additives. They
are used to cool and
lubricate tools and
working surfaces in a
variety of industrial
machining and grinding operations.
othoNirotoluine (88722)........... orthoNitrotoluene is NIEHS \1\.............. Results of a NTP
used to synthesize bioassay (TR 504,
agricultural and 2002), which reported
rubber chemicals, azo clear evidence of
and sulfur dyes, and carcinogenicity in
dyes for cotton, wool, rats and mice. silk, leather, and
paper.
Oxazepam (604751).................. Oxazepam is a NIEHS \1\.............. Results of a NTP
benzodiazepine used bioassay (TR 443,
extensively since the 1993), which reported
1960s for the clear evidence of
treatment of anxiety carcinogenicity in
and insomnia and in male and female mice. the control of
symptoms of alcohol withdrawal.
Riddelliine (232476960)............ Riddelliine is found in NIEHS \1\.............. Results of a NTP
a class of plants bioassay (TR 508,
growing in western 2003), which reported
United States. Cattle, clear evidence of
horses and sheep carcinogenicity in
ingest these toxic male and female rats
plants. Residues have and mice.
been found in, milk, and honey.
Styrene (100425)................... Styrene is used in the Lorenzo Tomatis........ IARC \2\ finding of
production of limited evidence of
polystyrene, carcinogenicity in
acrylonitrile animals and limited
butadienestyrene evidence of
resins, styrene carcinogenicity in
butadiene rubbers and humans (Vol. 82,
latexes, and 2002). unsaturated
polystyrene resins.
Talc Two nominations (1) Cosmetic Talc occurs in various NIEHS \1\.............. The NTP deferred
talc (2) Occupational exposure to geological settings consideration of
talc. around the world. listing talc
Exposure to general (asbestiform and non
population occurs asbestiform talc) in
through use of the 10th RoC because
products such as its 2000 review of
cosmetics. talc found confusion
Occupational exposure in the scientific
occurs during mining, literature over the
milling and processing. mineral nature of
talc. Given the
confusion over
defining exposure to
talc based on
asbestiform fibers,
the NPT has decided
that the most
appropriate approach
would be to
characterize talc
exposure as cosmetic
talc and occupational
exposure to talc. The
basis for the review
of talc is as follows:
Cosmetic talc: Human
epidemiological
studies reporting an
increased risk of
ovarian cancer among
women using talc for
personal use.
Occupational exposure
to talc: Human
epidemiological
studies reporting an
increase risk of
cancer among workers
exposed to talc.
Teniposide (29767202).............. Teniposide is a DNA NIEHS \1\.............. IARC \2\ finding of
toposiomerase II limited evidence of
inhibitors used mainly carcinogenicity in
in the treatment of humans (Vol. 76,
adult childhood 2000). leukemia.
[[Page 28944]]
Vinyl MonoHalides as a class........ Vinyl halides are used NIEHS\1\............... Vinyl Fluoride and
in the production of Vinyl Bromide are
polymers and currently listed in
copolymers. Vinyl the RoC as reasonably
bromide is mainly used anticipated to be a
in polymers as a flame human carcinogen and
retardant and in the Vinyl Chloride is
production of currently listed in
monoacrylic fibers of the RoC as known to be
carpetbacking a human carcinogen in
materials. Vinyl the Report on
Chloride is used to Carcinogens.
produce polyvinyl Vinyl MonoHalides:
chloride and Structural
copolymers. Vinyl similarities and
Fluoride is used in common mechanisms of
the production of tumor formation.
polyvinyl fluoride,
which when laminated
with aluminum, steel
and other materials is
used as a protective surface for the
exteriors of
residential and
commercial buildings.
\1\ The National Institute of Environmental Health Sciences (NIEHS). \2\ International Agency for Research on Cancer (IARC).
[FR Doc. 0411359 Filed 51804; 8:45 am]
BILLING CODE 414001P
SUMMARY:
National Toxicology Program—; Carcinogens Report, Twelfth Edition; substances, mixtures, and exposure circumstances proposed for listing; comment request,
DOCUMENT BODY 2:
Background
The National Toxicology Program (NTP) announces its intent to review additional agents, substances, mixtures and exposure circumstances for possible listing in the Report on Carcinogens (RoC), Twelfth Edition that is scheduled for publication in 2006. This Report (previously known as the Annual Report on Carcinogens) is a Congressionally mandated listing of known human carcinogens and reasonably anticipated human carcinogens and its preparation is delegated to the NTP by the Secretary, Department of Health and Human Services (DHHS). Section 301(b)(4) of the Public Health Service Act, as amended, provides that the Secretary, DHHS shall publish a report, which contains a list of all substances (1) which either are known to be human carcinogens or may reasonably be anticipated to be human carcinogens, and (2) to which a significant number of persons residing in the United States (US) are exposed. The law also states that the reports should provide available information on the nature of exposures, the estimated number of persons exposed and the extent to which the implementation of Federal regulations decreases the risk to public health from exposure to these chemicals.
A nomination recommended for review in the RoC is evaluated
initially by the NIEHS/NTP RoC nomination review committee, composed of
scientists from the NIEHS/NTP staff, to determine if the information
available for a nomination indicates the criteria for listing can be
applied and warrants formal consideration by the NTP. The scientific
review of a nomination involves three separate scientific reviews: two
Federal review groups and one nongovernment peer review body (a
subcommittee of the NTP Board of Scientific Counselors) that meets in
an open, public forum. Throughout the review process, multiple
opportunities are provided for public input including comment at the
public meeting of the NTP Board RoC Subcommittee. In reviewing
nominations for the RoC, all available data and public comments are
considered in the application of the criteria for inclusion or removal of candidate agents, substances, mixtures
[[Page 28941]]
or exposure circumstances or for a change in a candidate's classification.
The criteria used in the review process and a detailed description
of the review procedures, including the steps in the current formal
review process, can be obtained from the NTP Web site at http://ntpserver.niehs.nih.gov (see Report on Carcinogens) or can be obtained by
contacting: Dr. C. W. Jameson, National Toxicology Program, Report on
Carcinogens, 79 Alexander Drive, Building 4401, Room 3118, P.O. Box
12233, Research Triangle Park, NC 27709; phone: (919) 5414096, fax:
(919) 5410144, email: jameson@niehs.nih.gov. Public Comment Requested
The following table identifies the 21 nominations that the NTP may consider for review in 2004 or 2005, as either a new listing in or changing the current listing in the Twelfth Report. These nominations are provided with their Chemical Abstracts Services (CAS) Registry numbers (where available) and pending review action. Additional nominations for the Twelfth Report or modifications to the nominations in the attached table may be identified and would be announced in future Federal Register notices. The NTP solicits public input on these 21 nominations and asks for relevant information concerning their carcinogenesis, as well as current production data, use patterns, or human exposure information. The NTP also invites interested parties to identify any scientific issues related to the listing of a specific nomination in the RoC that they feel should be addressed during the reviews. Comments concerning these nominations for listing in or changing the current listing in the Twelfth Report on Carcinogens will be accepted for a period of 60 days from the publication date of this announcement in the Federal Register. Individuals submitting public comments are asked to include relevant contact information (name, affiliation (if any), address, telephone, fax, and email). Comments or questions should be directed to Dr. C. W. Jameson at the address listed above.
Additional Nominations Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for review for the Twelfth and future RoCs. Nominations should
contain a rationale for review. Appropriate background information and
relevant data (e.g., journal articles, NTP Technical Reports, IARC
listings, exposure surveys, release inventories, etc.), which support
the review of a nomination, should be provided or referenced when
possible. Contact information for the nominator should also be included
(name, affiliation (if any), address, telephone, fax, and email).
Nominations should be sent to Dr. Jameson's attention at the address given above.
Dated: May 10, 2004.
Kenneth Olden,
Director, National Toxicology Program.
Summary for Agents, Substances, Mixtures or Exposure Circumstances To Be Reviewed in 20042005 for Possible
Listing the Report on Carcinogens, Twelfth Edition Primary uses or
Nomination to be reviewed/CAS No. exposures Nominated by Basis for nomination
AristolochiaRelated Remedies........ Several Aristolochia NIEHS \1\.............. Herbal remedies
Herbal species containing the plant
(notably A. contorta, genus Aristolochia:
A. debilis, A. fangchi IARC \2\ finding of
and A. manshuriensis) sufficient evidence of
have been used in carcinogenicity in
traditional Chinese humans (Vol. 83,
medicine as anti 2002). rheumatics, as
diuretics, in the
treatment of edema and
for other conditions
such as hemorrhoids, coughs and asthma.
Aristolochic Acid................... Aristolochic acid, the NIEHS \1\.............. Naturally occurring
principle extract from mixtures of
Aristolochia, is a aristolochic acids:
mixture of IARC \2\ finding of
nitrophenanthrene sufficient evidence of
carboxylic acids. carcinogenicity in
animals and limited
evidence in humans
(Vol. 83, 2002).
Asphalt fumes........................ Asphalt is a petroleum John Schelp of NAACP Human epidemiological
product used in paving Durham Chapter. studies have reported
and roofing an increased risk in
operations. Asphalt lung cancer among
fumes are a cloud of workers exposed to
small particles asphalt fumes and
generated from the asphalt fumes caused
gaseous state after skin tumors in
volatilization of experimental animals.
asphalt aggregates. Additionally, known
human carcinogens
(PAHs) have been found
in asphalt fumes.
Atrazine (192249).................. Atrazine is an NIEHS \1\.............. IARC \2\ finding of
herbicide used to sufficient evidence of
control grass and carcinogenicity in
broadleaved weeds. animals (Vol. 73,
Atrazine has been 1999). detected at levels
that exceeded or
approached the MCL for atrazine in 200
community surface
drinking water system. [[Page 28942]]
Benzofuran (271896)................ Benzofuran is produced NIEHS \1\.............. Results of a NTP
by isolation from coal bioassay (TR 370,
tar oils. Benzofuran 1989) that reported
is used in the clear evidence of
manufacture of carcinogenicity in
coumaroneindene male and female mice
resins, which harden and some evidence of
when heated and are carcinogenicity in
used to make floor female rats. titles and other
products.
Captafol (24250601)................ Captafol is a fungicide NIEHS \1\.............. IARC \2\ finding of
that has been widely sufficient evidence of
used since 1961 for carcinogenicity in
the control of fungal animals (Vol. 53,
diseases in fruits, 1991). IARC also noted
vegetables and some that captafol is
other plants. Use of positive in many
captafol in the United genetic assays,
States was banned in including the invivo
1999. assay for dominant
lethal mutation.
Cobalt/TungstenCarbide Hard Metal Hardmetals are NIEHS \1\.............. Recent human cancer
Manufacturing. manufactured by a studies on the hard
process of powder metal manufacturing
metallurgy from industry an
tungsten and carbon association between
(tungsten carbide), exposure to hard
and small amounts of metals (cobalt
other metallic tungstencarbide) and
compounds using cobalt lung cancer. as a binder. Hard
metals are used to
make cutting and
grinding tools, dies,
and wear products for
a broad spectrum of
industries including
oil and gas drilling, and mining.
Di (2ethylhexyl) phthalate (DEHP) DEHP is mainly used as Jun KiChul, President Currently listed in the
(117817). a plasticizer in of Aekyung RoC as reasonably
polyvinyl chloride Petrochemical Co., LTD anticipated to be a
(PVC) resins for of Seoul, Korea (for human carcinogen.
fabricating flexible delisting). IARC reclassification
vinyl products. PVC as not classifiable as
resins have been used to its carcinogenicity
to manufacture toys, to humans (Group 3)
dolls, vinyl (Vol. 73, 2000). IARC
upholstery, stated that there is
tablecloths and many sufficient evidence
other products. for the
carcinogenicity in
experimental animals;
however, the mechanism
for liver tumor
involves peroxisome
proliferation that is
not relevant to
humans.
Etoposide in combination with Etoposide in NIEHS \1\.............. IARC \2\ finding of
cisplatin and bleomycin. combination with sufficient evidence of
cisplatin and carcinogenicity in
bleomycin is used to humans (Vol 76, 2000).
treat testicular germ cell cancers.
Etoposide (33419420)............... Etoposide is a DNA NIEHS \1\.............. IARC \2\ finding of
topoisomerase II limited evidence of
inhibitor used in carcinogenicity in
chemotherapy for non humans (Vol. 76,
Hodgkin's lymphoma, 2000). smallcell lung
cancer, testicular
cancer, lymphomas and
a variety of childhood malignancies.
Glass wool (respirable size): Two The major uses of glass North American Glass wool (respirable
nominations: (1) Insulation glass wool are in thermal, Insulation size) is currently
wool fibers (2) Special purposes electrical, and Manufacturers listed in the RoC as
glass fibers. acoustical insulation, Association nominated reasonably anticipated
weatherproofing, and glass wool (respirable to be a human
filtration media. In size) for delisting. carcinogen.
1980, approximately Special purpose glass Insulation glass wool:
80% of the glass wool wool fibers: NIEHS \1\. IARC \2\ finding of
produced for limited evidence of
structural insulation carcinogenicity in
was used in houses. animals and evaluation
Special purpose fibers as not classifiable as
are used for high to its carcinogenicity
efficiency air to humans (Group 3)
filtration media, and (Vol. 81, 2002).
acid battery Specialpurpose glass
separators. fibers: IARC \2\
finding of sufficient
evidence of
carcinogenicity in
animals (Vol. 81,
2002). [[Page 28943]]
Metalworking Fluids.................. Metal working fluids NIEHS \1\.............. Recent human cancer
are complex mixtures studies of metal
that may contain working fluid that
mixtures of oil, show an association
emulsifiers, antiweld between exposure to
agents, corrosion these materials and
inhibitors, extreme cancer at several
pressure additives, tissue sites.
buffers biocides and
other additives. They
are used to cool and
lubricate tools and
working surfaces in a
variety of industrial
machining and grinding operations.
othoNirotoluine (88722)........... orthoNitrotoluene is NIEHS \1\.............. Results of a NTP
used to synthesize bioassay (TR 504,
agricultural and 2002), which reported
rubber chemicals, azo clear evidence of
and sulfur dyes, and carcinogenicity in
dyes for cotton, wool, rats and mice. silk, leather, and
paper.
Oxazepam (604751).................. Oxazepam is a NIEHS \1\.............. Results of a NTP
benzodiazepine used bioassay (TR 443,
extensively since the 1993), which reported
1960s for the clear evidence of
treatment of anxiety carcinogenicity in
and insomnia and in male and female mice. the control of
symptoms of alcohol withdrawal.
Riddelliine (232476960)............ Riddelliine is found in NIEHS \1\.............. Results of a NTP
a class of plants bioassay (TR 508,
growing in western 2003), which reported
United States. Cattle, clear evidence of
horses and sheep carcinogenicity in
ingest these toxic male and female rats
plants. Residues have and mice.
been found in, milk, and honey.
Styrene (100425)................... Styrene is used in the Lorenzo Tomatis........ IARC \2\ finding of
production of limited evidence of
polystyrene, carcinogenicity in
acrylonitrile animals and limited
butadienestyrene evidence of
resins, styrene carcinogenicity in
butadiene rubbers and humans (Vol. 82,
latexes, and 2002). unsaturated
polystyrene resins.
Talc Two nominations (1) Cosmetic Talc occurs in various NIEHS \1\.............. The NTP deferred
talc (2) Occupational exposure to geological settings consideration of
talc. around the world. listing talc
Exposure to general (asbestiform and non
population occurs asbestiform talc) in
through use of the 10th RoC because
products such as its 2000 review of
cosmetics. talc found confusion
Occupational exposure in the scientific
occurs during mining, literature over the
milling and processing. mineral nature of
talc. Given the
confusion over
defining exposure to
talc based on
asbestiform fibers,
the NPT has decided
that the most
appropriate approach
would be to
characterize talc
exposure as cosmetic
talc and occupational
exposure to talc. The
basis for the review
of talc is as follows:
Cosmetic talc: Human
epidemiological
studies reporting an
increased risk of
ovarian cancer among
women using talc for
personal use.
Occupational exposure
to talc: Human
epidemiological
studies reporting an
increase risk of
cancer among workers
exposed to talc.
Teniposide (29767202).............. Teniposide is a DNA NIEHS \1\.............. IARC \2\ finding of
toposiomerase II limited evidence of
inhibitors used mainly carcinogenicity in
in the treatment of humans (Vol. 76,
adult childhood 2000). leukemia.
[[Page 28944]]
Vinyl MonoHalides as a class........ Vinyl halides are used NIEHS\1\............... Vinyl Fluoride and
in the production of Vinyl Bromide are
polymers and currently listed in
copolymers. Vinyl the RoC as reasonably
bromide is mainly used anticipated to be a
in polymers as a flame human carcinogen and
retardant and in the Vinyl Chloride is
production of currently listed in
monoacrylic fibers of the RoC as known to be
carpetbacking a human carcinogen in
materials. Vinyl the Report on
Chloride is used to Carcinogens.
produce polyvinyl Vinyl MonoHalides:
chloride and Structural
copolymers. Vinyl similarities and
Fluoride is used in common mechanisms of
the production of tumor formation.
polyvinyl fluoride,
which when laminated
with aluminum, steel
and other materials is
used as a protective surface for the
exteriors of
residential and
commercial buildings.
\1\ The National Institute of Environmental Health Sciences (NIEHS). \2\ International Agency for Research on Cancer (IARC).
[FR Doc. 0411359 Filed 51804; 8:45 am]
BILLING CODE 414001P