Federal Register: October 25, 2004 (Volume 69, Number 205)
DOCID: FR Doc 04-23788
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
NOTICE: NOTICES
ACTION: National Toxicology Program:
SUBJECT CATEGORY:
National Toxicology Program; Call for Additional Public Comments on 21 Substances, Mixtures and Exposure Circumstances Proposed for Review for Listing or Changing the Current Listing in the Report on Carcinogens, Twelfth Edition
DOCUMENT SUMMARY:
Background
The National Toxicology Program (NTP) initially announced its
intent to review additional agents, substances, mixtures and exposure
circumstances for possible listing or changing the current listing in
the Report on Carcinogens (RoC), Twelfth Edition in a May 19, 2004
Federal Register notice (69 FR 28940 (May 19, 2004)). Based on some of
the comments received in response to this notice, the NTP is concerned
that there might have been confusion about the procedures that will be
used for review of nominations to the 12th RoC. A detailed description
of the current review procedures, including the steps in the formal
review process, is available on the Web at http://ntpserver.niehs.nih.gov (select on Report on Carcinogens) or can be
obtained by contacting: Dr. C.W. Jameson, National Toxicology Program,
Report on Carcinogens, 79 Alexander Drive, Building 4401, Room 3118, PO
Box 12233, Research Triangle Park, NC 27709; phone: (919) 5414096,
fax: (919) 5410144, email: jameson@niehs.nih.gov. Public Comment Requested
Because of the possibility of confusion over the review procedures for the 12th RoC nominations, additional comments concerning the nominations for listing or changing the current listing in the 12th RoC will be accepted by the NTP for a period of 30 days from the publication date of this announcement in the Federal Register. The following table identifies the 21 nominations the NTP may consider for review in 2004 or 2005, as either a new listing in or changing the current listing in the 12th RoC. These nominations are provided with their Chemical Abstracts Services (CAS) Registry numbers (where available) and pending review action. Additional nominations for the 12th RoC or modifications to the nominations in the attached table may be identified and would be announced in future Federal Register notices. The NTP solicits public input on these 21 nominations and asks for relevant information concerning their carcinogenesis, as well as current production data, use patterns, or human exposure information. The NTP also invites interested parties to identify any scientific issues related to the listing of a specific nomination in the RoC that they feel should be addressed during the reviews.
Individuals who submitted comments in response to the May 19, 2004 Federal Register (69 FR 28940 (May 19, 2004)) that initially announced the 12th RoC nominations need not resubmit their comments as they are already part of the public record. Individuals submitting new or additional public comments are asked to include relevant contact information (name, affiliation (if any), address, telephone, fax, and email). Comments or questions should be directed to Dr. C.W. Jameson at the address listed above.
Additional Nominations Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for review for the Twelfth and future RoCs. Nominations should
contain a rationale for review. Appropriate background information and
relevant data (e.g., journal articles, NTP Technical Reports, IARC
listings, exposure surveys, release inventories, etc.), which support
the review of a nomination, should be provided or referenced when
possible. Contact information for the nominator should also be included
(name, affiliation (if any), address, telephone, fax, and email).
Nominations should be sent to Dr. Jameson's attention at the address given above.
Dated: October 15, 2004.
Samuel Wilson,
Deputy Director, National Institute of Environmental Health Sciences. [[Page 62277]]
Summary for Agents, Substances, Mixtures or Exposure Circumstances To Be Reviewed in 20042005 for Possible
Listing the Report on Carcinogens, Twelfth Edition Nomination to be reviewed/CAS
number Primary uses or exposures Nominated by Basis for nomination
AristolochiaRelated Herbal Several Aristolochia NIEHS \1\............ Herbal remedies
Remedies. species (notably A. containing the plant
contorta, A. debilis, A. genus Aristolochia: IARC
fangchi and A. \2\ finding evidence of
manshuriensis) have been carcinogenicity in
used in traditional humans (Vol. 83, 2002).
Chinese medicine as anti rheumatics, as
diruretics, in the
treatment of edema and
for other conditions such
as hemorrhoids, coughs and asthma.
Aristolochic Acid................. Aristolochic acid, the NIEHS \1\............ Naturally occurring
principle extract from mixtures of aristolochic
Aristolochia, is a acids: IARC \2\ finding
mixture of of sufficient evidence
nitrophenanthrene of carcinogenicity in
carboxylic acids. animals and limited
evidence in humans (Vol.
83, 2002).
Asphalt fumes..................... Asphalt is a petroleum John Schelp of NAACP Human epidemiological
product used in paving Durham Chapter. studies have reported an
and roofing operations. increased risk in lung
Asphalt fumes are a cloud cancer among workers
of small particles exposed to asphalt fumes
generated from the and asphalt fumes caused
gaseous state after skin tumors in
volatilization of asphalt experimental animals.
aggregates. Additionally, known
human carcinogens (PAHs)
have been found in
asphalt fumes.
Atrazine (192249)............... Atrazine is an herbicide NIEHS \1\............ IARC \2\ finding of
used to control grass and sufficient evidence of
broadleaved weeks. carcinogenicity in
Atrazine has been animals (Vol. 73, 1999).
detected at levels that
exceeded or approached
the MCL for atrazine in 200 community surface
drinking water systems.
Benzofuran (271896)............. Benzofuran is produced by NIEHS \1\............ Results of a NTP bioassay
isolation from coaltar (TR 370, 1989), which
oils. Benzofuran is used reported clear evidence
in the manufacture of of carinogenicity in
coumaroneindene resins, male and female mice and
which harden when heated some evidence of
and are used to make carcinogenicity in
floor titles and other female rats. products.
Captafol (24250601)............. Captafol is a fungicide NIEHS \1\............ IARC \2\ finding of
that has been widely used sufficient evidence of
since 1961 for the carcinogenicity in
control of fungal animals (Vol. 53, 1991).
diseases in fruits, IARC also noted that
vegetables and some other captafol is positive in
plants. Use of captafol many genetic assays,
in the United States was including the invivo
banned in 1999. assay for dominant
lethal mutation.
Cobalt/TungstenCarbide Hard Metal Hardmetals are NIEHS \1\............ Recent human cancer
Manufacturing. manufactured by a process studies on the hard
of powder metallurgy from metal manufacturing
tungsten and carbon industry showing an
(tungsten carbide), and association between
small amounts of other exposure to hard metals
metallic compounds using (cobalt tungsten
cobalt as a binder. Hard carbide) and lung
metals are used to make cancer. cutting and grinding
tools, dies, and wear
products for a broad
spectrum of industries including oil and gas
drilling, and mining.
Di (2Ethylhexyl) phthalate (DEHP) DEHP is mainly used as a Jun KiChul, Currently listed in the
(117817). plasticizer in polyvinyl President of Aekyung RoC as reasonably
chloride (PVC) resins for Petrochemical Co., anticipated to be a
fabricating flexible LTD of Seoul, Korea human carcinogen.
vinyl products. PVC (for delisting). IARC reclassification as
resins have been used to not classifiable as to
manufacture toys, dolls, its carcinogenicity to
vinyl upholstery, humans (Group 3) (Vol.
tablecloths and many 73, 2000). IARC stated
other products. that there was
sufficient evidence for
the carcinogenicity in
experimental animals;
however, the mechanism
for liver tumor involves
peroxisome proliferation
that is not relevant to
humans.
Etoposide in combination with Etoposide in combination NIEHS \1\............ IARC \2\ finding of
cisplatin and bleomycin. with cisplating and sufficient evidence of
bleomycin is used to carcinogenicity in
treat testicular germ humans (Vol. 76, 2000). cell cancers.
Etoposide (33419420)............ Etoposide is a DNA NIEHS \1\............ IARC \2\ finding of
topoisomerase II limited evidence of
inhibitor used in carcinogenicity in
chemotherapy for non humans (Vol. 76, 2000). Hodgkin's lyumphoma,
smallcell lung cancer, testicular cancer,
lymphomas and a variety
of childhood malignancies. [[Page 62278]]
Glass wool (respirable size): Two The major uses of glass North American Glass wool (respirable
nominations: wool are in thermal, Insulation size) is currently
(1) Insulation glass wool fibers. electrical, and Manufacturers listed in the RoC as
(2) Special purposes glass fibers. acoustical insulation, Association reasonably anticipated
weatherproofing, and nominated glass wool to be a human
filtration media. In (respirable size) carcinogen.
1980, approximately 80% for delisting. Insulation glass wool:
of the glass wool Special purpose glass IARC \2\ finding of
produced for structural wool fibers: NIEHS limited evidence of
insulation was used in \1\. carcinogenicity in
houses. Special purpose animals and evaluation
fibers are used for high as not classifiable as
efficiency air filtration to its carcinogenicity
media, and acid battery to humans (Group 3)
separators. (Vol. 81, 2002).
Specialpurpose glass
fibers: IARC \2\ finding
of sufficient evidence
of carcinogenicity in
animals (Vol. 81, 2002).
Metalworking Fluids............... Metal working fluids are NIEHS \1\............ Recent human cancer
complex mixtures that may studies of metal working
contain mixtures of oil, fluid that show an
emulsifiers, antiweld association between
agents, corrosion exposure to these
inhibitors, extreme materials and cancer at
pressure additives, several tissue sites. buffers biocides and
other additives. They are used to cool and
lubricate tools and
working surfaces in a
variety of industrial
machining and grinding operations.
othoNitrotolume (88722)........ orthoNitrotoluene is used NIEHS \1\............ Results of a NTP bioassay
to synthesize (TR 504, 2002), which
agricultural and rubber reported clear evidence
chemicals, azo and sulfur of carcinogenicity in
dyes, and dyes for rats and mice. cotton, wool, silk,
leather, and paper.
Oxazepam (604751)............... Oxazepam is a NIEHS \1\............ Results of a NTP bioassay
benzodiazepine used (TR 443, 1993), which
extensively since the reported clear evidence
1960s for the treatment of carcinogenicity in
of anxiety and insomnia male and female mice. and in the control of
symptoms of alcohol
withdrawal.
Riddelliine (23246960).......... Riddelliine is found in NIEHS \1\............ Results of a NTP bioassay
class of plants growing (TR 508, 2003), which
in western US. Cattle, reported clear evidence
horses and sheep ingest of carcinogenicity in
these toxic plants. male and female rats and
Residues have been found mice. in milk and honey.
Styrene (100425)................ Styrene is used in the Lorenzo Tomatis...... IARC \2\ finding of
production of limited evidence of
polystyrene, carcinogenicity in
acrylonitrilebutadiene animals and limited
styreen resins, styrene evidence of
butadiene rubbers and carcinogenicity in
latexes, and unsaturated humans (Vol. 82, 2002). polystyrene resins.
TalcTwo nominations............. Talc occurs in various NIEHS \1\............ The NTP deferred
(1) Cosmetic talc................. geological settings consideration of listing
Occupational exposure to talc..... around the world. talc (asbestiform and
Exposure to general nonasbestiform talc) in
population occurs through the 20th RoC because its
use of products such as 2000 review of talc
cosmetics. Occupational found confusion in the
exposure occurs during scientific literature
mining, milling and over the mineral nature
processing. of talc. Given the
confusion over defining
exposure to talc based
on asbestiform fibers,
the NTP has decided that
the most appropriate
approach would be to
characterize talc
exposure as cosmetic
talc and occupational
exposure to talc. The
basis for the review of
talc is as follows:
Cosmetic talc: Human
epidemiological studies
reporting an increased
risk of ovarian cancer
among women using talc
for personal use.
Occupational exposure to
talc: Human
epidemiological studies
reporting an increase
risk of cancer among
workers exposed to talc.
Teniposide (29767202)........... Teniposide is a DNA NIEHS \1\............ IARC \2\ finding of
topoisomerase II limited evidence of
inhibitors used mainly in carcinogenicity in
the treatment of adult humans (Vol. 76, 2000).
and childhood leukemia. [[Page 62279]]
Vinyl MonoHalides as a class..... Vinyl halides are used in NIEHS \1\............ Vinyl Fluoride and Vinyl
the production of Bromide are currently
polymers and copolymers. listed in the RoC as
Vinyl bromide is mainly reasonably anticipated
used in polymers as a to be a human carcinogen
flame retardant and in and Vinyl Chloride is
the production of currently listed in the
monoacrylic fibers for RoC as known to be a
carpetbacking materials. human carcinogen in the
Vinyl Chloride is used to Reports on Carcinogens.
produced polyvinyl Vinyl MonoHalides:
chloride and copolymers. Structural similarities
Vinyl Fluoride is used in and common mechanisms of
the production of tumor formation.
polyvinyl fluoride, which when laminated with
aluminum, steel and other
materials is used as a
protective surface for the exteriors of
residential and
commercial buildings.
\1\ The National Institute of Environmental Health Sciences (NIEHS). \2\ International Agency for Research on Cancer (IARC).
[FR Doc. 0423788 Filed 102204; 8:45 am]
BILLING CODE 414001P
SUMMARY:
Carcinogens Report, Twelfth Edition—; Agents, substances, mixtures, and exposure circumstances for listing or delisting,
DOCUMENT BODY 2:
Background
The National Toxicology Program (NTP) initially announced its
intent to review additional agents, substances, mixtures and exposure
circumstances for possible listing or changing the current listing in
the Report on Carcinogens (RoC), Twelfth Edition in a May 19, 2004
Federal Register notice (69 FR 28940 (May 19, 2004)). Based on some of
the comments received in response to this notice, the NTP is concerned
that there might have been confusion about the procedures that will be
used for review of nominations to the 12th RoC. A detailed description
of the current review procedures, including the steps in the formal
review process, is available on the Web at http://ntpserver.niehs.nih.gov (select on Report on Carcinogens) or can be
obtained by contacting: Dr. C.W. Jameson, National Toxicology Program,
Report on Carcinogens, 79 Alexander Drive, Building 4401, Room 3118, PO
Box 12233, Research Triangle Park, NC 27709; phone: (919) 5414096,
fax: (919) 5410144, email: jameson@niehs.nih.gov. Public Comment Requested
Because of the possibility of confusion over the review procedures for the 12th RoC nominations, additional comments concerning the nominations for listing or changing the current listing in the 12th RoC will be accepted by the NTP for a period of 30 days from the publication date of this announcement in the Federal Register. The following table identifies the 21 nominations the NTP may consider for review in 2004 or 2005, as either a new listing in or changing the current listing in the 12th RoC. These nominations are provided with their Chemical Abstracts Services (CAS) Registry numbers (where available) and pending review action. Additional nominations for the 12th RoC or modifications to the nominations in the attached table may be identified and would be announced in future Federal Register notices. The NTP solicits public input on these 21 nominations and asks for relevant information concerning their carcinogenesis, as well as current production data, use patterns, or human exposure information. The NTP also invites interested parties to identify any scientific issues related to the listing of a specific nomination in the RoC that they feel should be addressed during the reviews.
Individuals who submitted comments in response to the May 19, 2004 Federal Register (69 FR 28940 (May 19, 2004)) that initially announced the 12th RoC nominations need not resubmit their comments as they are already part of the public record. Individuals submitting new or additional public comments are asked to include relevant contact information (name, affiliation (if any), address, telephone, fax, and email). Comments or questions should be directed to Dr. C.W. Jameson at the address listed above.
Additional Nominations Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for review for the Twelfth and future RoCs. Nominations should
contain a rationale for review. Appropriate background information and
relevant data (e.g., journal articles, NTP Technical Reports, IARC
listings, exposure surveys, release inventories, etc.), which support
the review of a nomination, should be provided or referenced when
possible. Contact information for the nominator should also be included
(name, affiliation (if any), address, telephone, fax, and email).
Nominations should be sent to Dr. Jameson's attention at the address given above.
Dated: October 15, 2004.
Samuel Wilson,
Deputy Director, National Institute of Environmental Health Sciences. [[Page 62277]]
Summary for Agents, Substances, Mixtures or Exposure Circumstances To Be Reviewed in 20042005 for Possible
Listing the Report on Carcinogens, Twelfth Edition Nomination to be reviewed/CAS
number Primary uses or exposures Nominated by Basis for nomination
AristolochiaRelated Herbal Several Aristolochia NIEHS \1\............ Herbal remedies
Remedies. species (notably A. containing the plant
contorta, A. debilis, A. genus Aristolochia: IARC
fangchi and A. \2\ finding evidence of
manshuriensis) have been carcinogenicity in
used in traditional humans (Vol. 83, 2002).
Chinese medicine as anti rheumatics, as
diruretics, in the
treatment of edema and
for other conditions such
as hemorrhoids, coughs and asthma.
Aristolochic Acid................. Aristolochic acid, the NIEHS \1\............ Naturally occurring
principle extract from mixtures of aristolochic
Aristolochia, is a acids: IARC \2\ finding
mixture of of sufficient evidence
nitrophenanthrene of carcinogenicity in
carboxylic acids. animals and limited
evidence in humans (Vol.
83, 2002).
Asphalt fumes..................... Asphalt is a petroleum John Schelp of NAACP Human epidemiological
product used in paving Durham Chapter. studies have reported an
and roofing operations. increased risk in lung
Asphalt fumes are a cloud cancer among workers
of small particles exposed to asphalt fumes
generated from the and asphalt fumes caused
gaseous state after skin tumors in
volatilization of asphalt experimental animals.
aggregates. Additionally, known
human carcinogens (PAHs)
have been found in
asphalt fumes.
Atrazine (192249)............... Atrazine is an herbicide NIEHS \1\............ IARC \2\ finding of
used to control grass and sufficient evidence of
broadleaved weeks. carcinogenicity in
Atrazine has been animals (Vol. 73, 1999).
detected at levels that
exceeded or approached
the MCL for atrazine in 200 community surface
drinking water systems.
Benzofuran (271896)............. Benzofuran is produced by NIEHS \1\............ Results of a NTP bioassay
isolation from coaltar (TR 370, 1989), which
oils. Benzofuran is used reported clear evidence
in the manufacture of of carinogenicity in
coumaroneindene resins, male and female mice and
which harden when heated some evidence of
and are used to make carcinogenicity in
floor titles and other female rats. products.
Captafol (24250601)............. Captafol is a fungicide NIEHS \1\............ IARC \2\ finding of
that has been widely used sufficient evidence of
since 1961 for the carcinogenicity in
control of fungal animals (Vol. 53, 1991).
diseases in fruits, IARC also noted that
vegetables and some other captafol is positive in
plants. Use of captafol many genetic assays,
in the United States was including the invivo
banned in 1999. assay for dominant
lethal mutation.
Cobalt/TungstenCarbide Hard Metal Hardmetals are NIEHS \1\............ Recent human cancer
Manufacturing. manufactured by a process studies on the hard
of powder metallurgy from metal manufacturing
tungsten and carbon industry showing an
(tungsten carbide), and association between
small amounts of other exposure to hard metals
metallic compounds using (cobalt tungsten
cobalt as a binder. Hard carbide) and lung
metals are used to make cancer. cutting and grinding
tools, dies, and wear
products for a broad
spectrum of industries including oil and gas
drilling, and mining.
Di (2Ethylhexyl) phthalate (DEHP) DEHP is mainly used as a Jun KiChul, Currently listed in the
(117817). plasticizer in polyvinyl President of Aekyung RoC as reasonably
chloride (PVC) resins for Petrochemical Co., anticipated to be a
fabricating flexible LTD of Seoul, Korea human carcinogen.
vinyl products. PVC (for delisting). IARC reclassification as
resins have been used to not classifiable as to
manufacture toys, dolls, its carcinogenicity to
vinyl upholstery, humans (Group 3) (Vol.
tablecloths and many 73, 2000). IARC stated
other products. that there was
sufficient evidence for
the carcinogenicity in
experimental animals;
however, the mechanism
for liver tumor involves
peroxisome proliferation
that is not relevant to
humans.
Etoposide in combination with Etoposide in combination NIEHS \1\............ IARC \2\ finding of
cisplatin and bleomycin. with cisplating and sufficient evidence of
bleomycin is used to carcinogenicity in
treat testicular germ humans (Vol. 76, 2000). cell cancers.
Etoposide (33419420)............ Etoposide is a DNA NIEHS \1\............ IARC \2\ finding of
topoisomerase II limited evidence of
inhibitor used in carcinogenicity in
chemotherapy for non humans (Vol. 76, 2000). Hodgkin's lyumphoma,
smallcell lung cancer, testicular cancer,
lymphomas and a variety
of childhood malignancies. [[Page 62278]]
Glass wool (respirable size): Two The major uses of glass North American Glass wool (respirable
nominations: wool are in thermal, Insulation size) is currently
(1) Insulation glass wool fibers. electrical, and Manufacturers listed in the RoC as
(2) Special purposes glass fibers. acoustical insulation, Association reasonably anticipated
weatherproofing, and nominated glass wool to be a human
filtration media. In (respirable size) carcinogen.
1980, approximately 80% for delisting. Insulation glass wool:
of the glass wool Special purpose glass IARC \2\ finding of
produced for structural wool fibers: NIEHS limited evidence of
insulation was used in \1\. carcinogenicity in
houses. Special purpose animals and evaluation
fibers are used for high as not classifiable as
efficiency air filtration to its carcinogenicity
media, and acid battery to humans (Group 3)
separators. (Vol. 81, 2002).
Specialpurpose glass
fibers: IARC \2\ finding
of sufficient evidence
of carcinogenicity in
animals (Vol. 81, 2002).
Metalworking Fluids............... Metal working fluids are NIEHS \1\............ Recent human cancer
complex mixtures that may studies of metal working
contain mixtures of oil, fluid that show an
emulsifiers, antiweld association between
agents, corrosion exposure to these
inhibitors, extreme materials and cancer at
pressure additives, several tissue sites. buffers biocides and
other additives. They are used to cool and
lubricate tools and
working surfaces in a
variety of industrial
machining and grinding operations.
othoNitrotolume (88722)........ orthoNitrotoluene is used NIEHS \1\............ Results of a NTP bioassay
to synthesize (TR 504, 2002), which
agricultural and rubber reported clear evidence
chemicals, azo and sulfur of carcinogenicity in
dyes, and dyes for rats and mice. cotton, wool, silk,
leather, and paper.
Oxazepam (604751)............... Oxazepam is a NIEHS \1\............ Results of a NTP bioassay
benzodiazepine used (TR 443, 1993), which
extensively since the reported clear evidence
1960s for the treatment of carcinogenicity in
of anxiety and insomnia male and female mice. and in the control of
symptoms of alcohol
withdrawal.
Riddelliine (23246960).......... Riddelliine is found in NIEHS \1\............ Results of a NTP bioassay
class of plants growing (TR 508, 2003), which
in western US. Cattle, reported clear evidence
horses and sheep ingest of carcinogenicity in
these toxic plants. male and female rats and
Residues have been found mice. in milk and honey.
Styrene (100425)................ Styrene is used in the Lorenzo Tomatis...... IARC \2\ finding of
production of limited evidence of
polystyrene, carcinogenicity in
acrylonitrilebutadiene animals and limited
styreen resins, styrene evidence of
butadiene rubbers and carcinogenicity in
latexes, and unsaturated humans (Vol. 82, 2002). polystyrene resins.
TalcTwo nominations............. Talc occurs in various NIEHS \1\............ The NTP deferred
(1) Cosmetic talc................. geological settings consideration of listing
Occupational exposure to talc..... around the world. talc (asbestiform and
Exposure to general nonasbestiform talc) in
population occurs through the 20th RoC because its
use of products such as 2000 review of talc
cosmetics. Occupational found confusion in the
exposure occurs during scientific literature
mining, milling and over the mineral nature
processing. of talc. Given the
confusion over defining
exposure to talc based
on asbestiform fibers,
the NTP has decided that
the most appropriate
approach would be to
characterize talc
exposure as cosmetic
talc and occupational
exposure to talc. The
basis for the review of
talc is as follows:
Cosmetic talc: Human
epidemiological studies
reporting an increased
risk of ovarian cancer
among women using talc
for personal use.
Occupational exposure to
talc: Human
epidemiological studies
reporting an increase
risk of cancer among
workers exposed to talc.
Teniposide (29767202)........... Teniposide is a DNA NIEHS \1\............ IARC \2\ finding of
topoisomerase II limited evidence of
inhibitors used mainly in carcinogenicity in
the treatment of adult humans (Vol. 76, 2000).
and childhood leukemia. [[Page 62279]]
Vinyl MonoHalides as a class..... Vinyl halides are used in NIEHS \1\............ Vinyl Fluoride and Vinyl
the production of Bromide are currently
polymers and copolymers. listed in the RoC as
Vinyl bromide is mainly reasonably anticipated
used in polymers as a to be a human carcinogen
flame retardant and in and Vinyl Chloride is
the production of currently listed in the
monoacrylic fibers for RoC as known to be a
carpetbacking materials. human carcinogen in the
Vinyl Chloride is used to Reports on Carcinogens.
produced polyvinyl Vinyl MonoHalides:
chloride and copolymers. Structural similarities
Vinyl Fluoride is used in and common mechanisms of
the production of tumor formation.
polyvinyl fluoride, which when laminated with
aluminum, steel and other
materials is used as a
protective surface for the exteriors of
residential and
commercial buildings.
\1\ The National Institute of Environmental Health Sciences (NIEHS). \2\ International Agency for Research on Cancer (IARC).
[FR Doc. 0423788 Filed 102204; 8:45 am]
BILLING CODE 414001P