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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

ATS ID: [ATSDR-235]

NOTICE: NOTICES

ACTION: Superfund program:

DOCUMENT ACTION: Request for comments on the proposed substances to be evaluated for Set 22 toxicological profiles.

SUBJECT CATEGORY: Proposed Substances To Be Evaluated for Set 22 Toxicological Profiles

DATES: Nominations must be submitted within 30 days of the publication of this notice. The 30day period begins October 26th, 2007 and ends November 26th, 2007.

DOCUMENT SUMMARY: This notice announces the list of proposed substances that will be evaluated for CERCLA Set 22
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toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

SUMMARY: Hazardous substances priority list (toxicological profiles),

SUPPLEMENTAL INFORMATION

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the Federal Register on December 7, 2005 (70 FR 702840). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014) and November 7, 2003 (68 FR 63098).
Proposed Substances To Be Evaluated for Set 22 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific literature. The following 73 substances will be evaluated:
Substance name CAS No. 1..................... PERFLUOROOCTANOIC ACID.......... (1) PERFLUOROCYL SULFONATES......... (1) 2..................... MERCURY......................... 007439976 METHYLMERCURY................... 022967926 MERCURIC CHLORIDE............... 007487947 3..................... POLYCHLORINATED BIPHENYLS....... 001336363 AROCLOR 1254.................... 011097691 AROCLOR 1260.................... 011096825 AROCLOR 1248.................... 012672296 AROCLOR 1242.................... 053469219 AROCLOR......................... 012767792 AROCLOR 1221.................... 011104282 AROCLOR 1016.................... 012674112 AROCLOR 1232.................... 011141165 AROCLOR 1240.................... 071328897 TETRACHLOROBIPHENYL............. 026914330 4..................... CADMIUM......................... 007440439 5..................... POLYCYCLIC AROMATIC HYDROCARBONS 130498292 BENZO(A)PYRENE.................. 000050328 BENZO(B)FLUORANTHENE............ 000205992 DIBENZO(A,H)ANTHRACENE.......... 000053703 BENZO(A)ANTHRACENE.............. 000056553 BENZO(K)FLUORANTHENE............ 000207089 BENZOFLUORANTHENE............... 056832736 FLUORANTHENE.................... 000206440 CHRYSENE........................ 000218019 ACENAPHTHENE.................... 000083329 INDENO(1,2,3CD)PYRENE.......... 000193395 BENZOPYRENE..................... 073467762 PHENANTHRENE.................... 000085018 PYRENE.......................... 000129000 FLUORENE........................ 000086737 ANTHRACENE...................... 000120127 BENZO(A)FLUORANTHENE............ 000203338 BENZO(GHI)PERYLENE.............. 000191242 ACENAPHTHYLENE.................. 000208968 BENZO(J)FLUORANTHENE............ 000205823 BENZO(E)PYRENE.................. 000192972 BENZOPERYLENE................... 011057457 BENZO(B)ANTHRACENE.............. 000092240 DIBENZ(A,J)ANTHRACENE........... 000224419 BENZO(GHI)FLUORANTHENE.......... 000203123 1METHYLPYRENE.................. 002381217 [[Page 60675]]
6..................... CHLOROFORM...................... 000067663 7..................... DDT, P,P'...................... 000050293 DDE, P,P'...................... 000072559 DDD, P,P'...................... 000072548 DDT, O,P'...................... 000789026 DDD, O,P'...................... 000053190 DDE, O,P'...................... 003424826 8..................... TRICHLOROETHYLENE............... 000079016 9..................... IELDRIN......................... 000060571 ALDRIN.......................... 000309002 10.................... CHROMIUM, HEXAVALENT............ 018540299 CHROMIUM(VI) OXIDE.............. 001333820 CHROMIUM........................ 007440473 CHROMIUM TRIOXIDE............... 007738945 CHROMIUM, TRIVALENT............. 016065831 11.................... CHLORDANE....................... 000057749 CISCHLORDANE................... 005103719 TRANSCHLORDANE................. 005103742 OXYCHLORDANE.................... 027304138 GAMMACHLORDENE................. 056641384 CHLORDANE, TECHNICAL............ 012789036 ALPHACHLORDENE................. 056534022 NONACHLOR, TRANS............... 039765805 NONACHLOR, CIS................. 005103731 CHLORDENE....................... 003734483 12.................... HEXACHLOROBUTADIENE............. 000087683 13.................... COAL TAR CREOSOTE............... 008001589 COAL TARS....................... 008007452 COAL TAR PITCH.................. 065996932 14.................... BENZIDINE....................... 000092875 15.................... TOXAPHENE....................... 008001352 16.................... TETRACHLOROETHYLENE............. 000127184 17.................... 1,2DIBROMOETHANE............... 000106934 18.................... DISULFOTON...................... 000298044 19.................... 3,3'DICHLOROBENZIDINE.......... 000091941 20.................... BERYLLIUM....................... 007440417 21.................... ENDRIN.......................... 000072208 ENDRIN KETONE................... 053494705 ENDRIN ALDEHYDE................. 007421934 22.................... 1,2DIBROMO3CHLOROPROPANE..... 000096128 DIBROMOCHLOROPROPANE............ 067708832 23.................... PENTACHLOROPHENOL............... 000087865 24.................... DINBUTYL PHTHALATE............ 000084742 25.................... ENDOSULFAN SULFATE.............. 001031078 ENDOSULFAN...................... 000115297 ENDOSULFAN, ALPHA............... 000959988 ENDOSULFAN, BETA................ 033213659 26.................... METHOXYCHLOR.................... 000072435 27.................... METHANE......................... 000074828 28.................... TOLUENE......................... 000108883 29.................... 2HEXANONE...................... 000591786 30.................... 2,3,7,8TETRACHLORODIBENZOP 001746016 DIOXIN.
HEXACHLORODIBENZOPDIOXIN...... 034465468 HEPTACHLORODIBENZOPDIOXIN..... 037871004 TETRACHLORODIBENZOPDIOXIN..... 041903575 PENTACHLORODIBENZOPDIOXIN..... 036088229 1,2,3,4,6,7,8HEPTACHLORODIBENZO 035822469 PDIOXIN.
OCTACHLORODIBENZOPDIOXIN...... 003268879 1,2,3,6,7,8HEXACHLORODIBENZOP 057653857 DIOXIN.
1,2,3,4,7,8HEXACHLORODIBENZOP 039227286 DIOXIN.
1,2,3,7,8,9HEXACHLORODIBENZOP 019408743 DIOXIN.
1,2,3,7,8PENTACHLORODIBENZOP 040321764 DIOXIN.
31.................... DI(2ETHYLHEXYL)PHTHALATE....... 000117817 32.................... 1,1DICHLOROETHENE.............. 000075354 33.................... METHYLENE CHLORIDE.............. 000075092 34.................... 2,4,6TRINITROTOLUENE........... 000118967 35.................... BROMODICHLOROETHANE............. 000683534 36.................... 1,2DICHLOROETHANE.............. 000107062 37.................... 2,4,6TRICHLOROPHENOL........... 000088062 TETRACHLOROPHENOL............... 025167833 2,4DICHLOROPHENOL.............. 000120832 2,4,5TRICHLOROPHENOL........... 000095954 2CHLOROPHENOL.................. 000095578 2,3,4,5TETRACHLOROPHENOL....... 004901513 [[Page 60676]]
2,3,5,6TETRACHLOROPHENOL....... 000935955 2,3,4,6TETRACHLOROPHENOL....... 000058902 4CHLOROPHENOL.................. 000106489 CHLOROPHENOL.................... 025167800 38.................... 2,4DINITROPHENOL............... 000051285 39.................... BIS(2CHLOROETHYL) ETHER........ 000111444 40.................... ASBESTOS........................ 001332214 CHRYSOTILE ASBESTOS............. 012001295 AMOSITE ASBESTOS................ 012172735 41.................... HEXACHLOROBENZENE............... 000118741 42.................... RADIUM226...................... 013982633 RADIUM.......................... 007440144 RADIUM228...................... 015262201 RADIUM224...................... 013233324 43.................... 2,4DINITROTOLUENE.............. 000121142 DINITROTOLUENE.................. 025321146 2,6DINITROTOLUENE.............. 000606202 44.................... ETHION.......................... 000563122 45.................... THORIUM......................... 007440291 THORIUM230..................... 014269637 THORIUM228..................... 014274829 46.................... 4,6DINITROOCRESOL............ 000534521 47.................... RADON........................... 010043922 RADON222....................... 014859677 RADON220....................... 022481487 48.................... CHLOROBENZENE................... 000108907 49.................... NNITROSODINPROPYLAMINE....... 000621647 50.................... MANGANESE....................... 007439965 MANGANESE DIOXIDE............... 001313139 51.................... POLONIUM210.................... 013981527 52.................... LEAD210........................ 014255040 53.................... CHLORPYRIFOS.................... 002921882 54.................... NEPTUNIUM237................... 013994202 55.................... CHLORDECONE..................... 000143500 MIREX........................... 002385855 56.................... S,S,STRIBUTYL 000078488 PHOSPHOROTRITHIOATE.
57.................... BROMINE......................... 007726956 58.................... 1,2,3TRICHLOROBENZENE.......... 000087616 59.................... DICOFOL......................... 000115322 60.................... PARATHION....................... 000056382 61.................... TRICHLOROFLUOROETHANE........... 027154332 62.................... TRIFLURALIN..................... 001582098 63.................... 4,4'METHYLENEBIS(2 000101144 CHLOROANILINE).
64.................... PENTACHLOROBENZENE.............. 000608935 65.................... 1,1DICHLOROETHANE.............. 000075343 66.................... 1,1,2TRICHLOROETHANE........... 000079005 67.................... 1,2,3,4,6,7,8,9 039001020 OCTACHLORODIBENZOFURAN.
HEPTACHLORODIBENZOFURAN......... 038998753 2,3,4,7,8 057117314 PENTACHLORODIBENZOFURAN.
HEXACHLORODIBENZOFURAN.......... 055684941 PENTACHLORODIBENZOFURAN......... 030402154 2,3,7,8TETRACHLORODIBENZOFURAN. 051207319 DIBENZOFURANS, CHLORINATED...... 042934532 1,2,3,4,6,7,8 067562394 HEPTACHLORODIBENZOFURAN.
1,2,3,7,8,9 072918219 HEXACHLORODIBENZOFURAN.
TETRACHLORODIBENZOFURAN......... 030402143 1,2,3,6,7,8 057117449 HEXACHLORODIBENZOFURAN.
1,2,3,4,7,8 070648269 HEXACHLORODIBENZOFURAN.
2,3,4,6,7,8 060851345 HEXACHLORODIBENZOFURAN.
1,2,3,7,8 057117416 PENTACHLORODIBENZOFURAN.
1,2,3,4,7,8,9 055673897 HEPTACHLORODIBENZOFURAN.
68.................... TRICHLOROETHANE................. 025323891 69.................... HEXACHLOROCYCLOPENTADIENE....... 000077474 70.................... 1,2DIPHENYLHYDRAZINE........... 000122667 71.................... NANOMATERIALS................... .............. 72.................... VANADIUM........................ 007440622 73.................... FORMALDEHYDE.................... 000050000 (1) Various.
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Submission of Nominations for the Evaluation Set 22

Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, email address, and telephone number.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

Email: jxt1@cdc.gov.

Fax: 770.488.4178.

Mail: CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA, 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Dated: October 19, 2007.
Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.
[FR Doc. E721018 Filed 102407; 8:45 am]
BILLING CODE 416370P

FOR FURTHER INFORMATION CONTACT Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 4883313.