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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Health and Human Services Department
NOTICE: NOTICES
ACTION: Naional Toxicology Program:
DOCUMENT ACTION: Announcement of public symposium and availability of document.
SUBJECT CATEGORY: National Toxicology Program (NTP); NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM); Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Ten-Year Anniversary Symposium and Five-Year Plan
DATES: The symposium will be held on February 5, 2008. Those interested in attending the symposium are encouraged to register with NICEATM by February 1, 2008, although registration will also be available onsite.
DOCUMENT SUMMARY: NICEATM invites attendance at a public symposium to mark the tenth anniversary of ICCVAM. The symposium, entitled ``Celebrating Ten Years of Advancing Public Health and Animal Welfare With Sound Science: Envisioning New Directions in Toxicology'' will be held February 5, 2008, at the U.S. Consumer Product Safety Commission (CPSC) Headquarters in Bethesda, MD. The NICEATMICCVAM FiveYear Plan (2008 2012) will also be discussed and made available on February 5.
SUMMARY: Interagency Center for Evaluation of Alternative Toxicological Methods; ten-year anniversary symposium and five-year plan,
SUPPLEMENTAL INFORMATION
BackgroundThe Director of the NIEHS established an ad hoc ICCVAM in September 1994 to respond to requirements in the NIH Revitalization Act of 1993 (42 U.S.C. 285l1, Public Law 10343). This Act required NIEHS to establish criteria for the validation and regulatory acceptance of alternative toxicological testing methods. NIEHS was also required to recommend a process to achieve the regulatory acceptance of scientifically valid alternative test methods. The ad hoc ICCVAM was comprised of representatives from 15 Federal agencies, which are now represented on ICCVAM.
In 1997, the ad hoc ICCVAM published its final report, Validation and Regulatory Acceptance of Toxicological Test Methods. In the same year, NIEHS established a standing ICCVAM committee to implement a process by which new test methods of interagency interest could be evaluated and to coordinate crossagency issues on development, validation, acceptance, and national and international harmonization of toxicological test methods. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l3, Public Law 106545) established ICCVAM as a permanent interagency committee of NIEHS under NICEATM. The law was enacted ``To establish, wherever feasible, guidelines, recommendations, and regulations that promote the regulatory acceptance of new or revised scientifically valid toxicological tests that protect human and animal health and the environment while reducing, refining, or replacing animal tests and ensuring human safety and product effectiveness.''
Over the last 10 years, ICCVAM, with scientific support from
NICEATM, has evaluated over 185 test methods with the potential to
reduce, refine or replace the use of animals in regulatory safety
testing. ICCVAM has developed and transmitted recommendations to
Federal agencies for alternative methods for the four most commonly
used toxicity tests. These sciencebased technical evaluations have
been used to support adoption of test methods as guidelines by the
Organisation for Economic Cooperation and Development and other
international organizations. NICEATM and ICCVAM have also worked with
Federal agencies and other stakeholders to link research and
development activities to the standardization and validation of
alternative test methods that may be used in regulatory testing. The
symposium on February 5, 2008, will recognize the 10year anniversary
of ICCVAM and discuss future directions in toxicology testing and the NICEATMICCVAM FiveYear Plan.
Preliminary Agenda
Symposium Attendance and Registration
The symposium will be held on Tuesday, February 5, 2008, from 15
p.m., in the CPSC Hearing Room, located at CPSC Headquarters, Bethesda
Towers Bldg., 4330 East West Highway, Bethesda, MD. The symposium is
open to the public and there is no charge to attend; attendance is
limited only by the available space. Individuals who plan to attend are
encouraged to register in advance with NICEATM. Registration
information is available on the NICEATMICCVAM Web site at http://iccvam.niehs.nih.gov/meetings/10thAnnivSymp/10thAnnivSymp.htm or by
contacting NICEATM (see FOR FURTHER INFORMATION CONTACT above). Persons
needing special assistance in order to attend, such as sign language
interpretation or other reasonable accommodation, should contact 919
5412475 voice, 9195414644 TTY (text telephone, through the Federal
TTY Relay System at 8008778339), or email to
niehsoeeo@niehs.nih.gov. Requests should be made at least seven days in advance of the event.
NICEATMICCVAM FiveYear Plan
NICEATM and ICCVAM, working in conjunction with Federal agency program offices, have prepared the NICEATMICCVAM FiveYear Plan. The plan describes how NICEATM and ICCVAM will facilitate the research, development, translation (activities carried out to characterize if there is evidence of relevance and applicability of a test method for a specific testing purpose), validation, and regulatory acceptance of alternative test methods. Acceptance of such methods will reduce, refine, and replace the use of animals in testing, while maintaining scientific quality and the protection of human health, animal health, and the environment. Development of the plan took place over a 14month period during which there were multiple opportunities for comment on the plan by ICCVAM stakeholders, the public, and the Scientific Advisory Committee on Alternative Toxicological Methods (see Federal Register notices: Vol. 71, No. 218, pp. 6617273, November 13, 2006; Vol. 72, No. 83, pp. 2383132, May 1, 2007; and Vol. 72, No. 83, pp. 2383233, May 1, 2007).
The plan addresses ICCVAM's vision to play a leading role in fostering and promoting the development, validation, and regulatory acceptance of scientifically sound alternative test methods both within the Federal government and internationally. Implementing this plan involves four key challenges. The first challenge is to identify priority areas for the next five years and to conduct and facilitate activities in those areas. The second challenge involves identifying and promoting research initiatives that are expected to support the future development of innovative alternative test methods. The third challenge is to foster the acceptance and appropriate use of alternative test methods through outreach and communication. The last challenge is to develop partnerships and strengthen interactions with ICCVAM stakeholders in order to facilitate meaningful progress.
The NICEATMICCVAM FiveYear Plan will be presented at the February
symposium and copies will be available. The NICEATMICCVAM FiveYear
Plan will also be available electronically after February 5 on the
NICEATMICCVAM Web site at http://iccvam.niehs.nih.gov/docs/5yearplan.htm. Print copies may be obtained by contacting NICEATM (see
FOR FURTHER INFORMATION CONTACT above).
Background Information on ICCVAM and NICEATM
ICCVAM is an interagency committee composed of representatives from
15 Federal regulatory and research agencies that use or generate toxicological information. ICCVAM conducts
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technical evaluations of new, revised, and alternative methods with
regulatory applicability and promotes the scientific validation and
regulatory acceptance of toxicological test methods that more
accurately assess the safety and hazards of chemicals and products and
that refine, reduce, or replace animal use. The ICCVAM Authorization
Act of 2000 (available at http://iccvam.niehs.nih.gov/docs/about_docs/PL106545.pdf ) establishes ICCVAM as a permanent interagency committee
of the NIEHS under NICEATM. NICEATM administers ICCVAM and provides
scientific and operational support for ICCVAMrelated activities.
NICEATM and ICCVAM work collaboratively to evaluate new and improved
test methods applicable to the needs of Federal agencies. Additional
information about ICCVAM and NICEATM is available on the NICEATMICCVAM
Web site at http://iccvam.niehs.nih.gov.
Dated: December 12, 2007.
Samuel H. Wilson,
Acting Director, National Institute of Environmental Health Sciences and National Toxicology Program.
[FR Doc. E724799 Filed 122007; 8:45 am]
BILLING CODE 414001P
FOR FURTHER INFORMATION CONTACT Ms. Debbie McCarley, NICEATM, NIEHS, P.O. Box 12233, MD EC17, Research Triangle Park, NC 27709, (telephone) 9195412384, (fax) 9195410947, (email) niceatm@niehs.nih.gov.
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